Multimodal Analgesia Multimodal analgesia is defined as a combination of systemic analgesics, like an NSAID and an opioid, or a combination of a systemic analgesic/s and a local anesthetic. Related Terms: Systemic AnalgesicPre-emptive AnalgesiaAnalgesiaAnesthesiaLocal AnestheticNonsteroidal Anti-Inflammatory (NSAID)Opioid