- \r\n \t
- No expired substance<\/a> or agent<\/a> can be used as a stand-alone product or as a component of any dilution in an animal activity.\r\n
- \r\n \t
- Substances and agents expire in accordance with manufacturer recommendations.<\/li>\r\n \t
- If the manufacturer recommendations include an expiration date and a beyond use date, the substance or agent expires on whichever date occurs first.<\/li>\r\n \t
- Sterile bags of fluids accessed and connected directly to an animal through the use of an intravenous line have a beyond use date of 30 days after initial puncture.<\/li>\r\n<\/ol>\r\n<\/li>\r\n \t
- Injectable agents and substances must be sterile and accessed aseptically. Review the Guidelines on the Preparation of Injectable Substances and Agents Administered to Animals<\/em><\/a> for more information.<\/li>\r\n \t
- Clearly label all substances and agents with their full name, concentration, and the relevant expiration or beyond use date.<\/li>\r\n \t
- Store all substances and agents in accordance with manufacturer expectations, U-M requirements, and State of Michigan and DEA regulations.<\/li>\r\n \t
- Clearly label expired items and segregate from non-expired items until they can be appropriately discarded.<\/li>\r\n<\/ol>","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area_with_subheading","legacy_heading":"","legacy_subheading":"Medical Materials","legacy_section_text":"
- \r\n \t
- Expired medical materials<\/a> and supplies\u00a0can be used for non-recovery<\/a> surgeries or non-recovery procedures provided that<\/em> their usage does not<\/strong><\/span> adversely affect the animal\u2019s well-being or potentially compromise the validity of the scientific study. These items must be:\r\n
- \r\n \t
- Clearly labeled (e.g., \u201cExpired: non-recovery use only\u201d)<\/li>\r\n \t
- Segregated from non-expired items<\/li>\r\n<\/ol>\r\n<\/li>\r\n \t
- Store all medical materials according to manufacturer recommendations.<\/li>\r\n<\/ol>","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"heading","legacy_heading":"Compliance","legacy_subheading":"Medical Materials","legacy_section_text":"
- \r\n\t
- Expired medical materials and supplies can be used for non-recovery surgeries or non-recovery procedures provided that their usage does not adversely affect the animal’s well-being or potentially compromise the validity of the scientific study. These items must be:\r\n\t
- \r\n\t\t
- Clearly labeled (e.g., “Expired: non-recovery use only”).<\/li>\r\n\t\t
- Segregated from non-expired items.<\/li>\r\n\t<\/ol>\r\n\t<\/li>\r\n\t
- Store all medical materials according to manufacturer recommendations.<\/li>\r\n<\/ol>","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area","legacy_heading":"Compliance","legacy_subheading":"","legacy_section_text":"The provisions of this policy are under the direction and oversight of the U-M\u2019s IACUC. The IACUC will, if necessary, suspend research or implement sanctions if policy infractions should occur.","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"heading","legacy_heading":"Appendices","legacy_subheading":"","legacy_section_text":"
The provisions of this policy are under the direction and oversight of the U-M’s IACUC. The IACUC will, if necessary, suspend research or implement sanctions if policy infractions should occur. <\/p>","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area_with_subheading","legacy_heading":"APPENDIX A: EXAMPLES OF EXPIRATION DATES","legacy_subheading":"Appendix A: Examples of Expiration Dates","legacy_section_text":"
\r\n\r\n
\r\n \r\nScenario<\/th>\r\n Last Day of Acceptable Use<\/th>\r\n<\/tr>\r\n<\/thead>\r\n \r\n The manufacturer guidelines for Carprofen (stock bottle has an expiration of 8\/5\/2023) state the product must be used within 28 days of first puncture. The drug is first accessed on 5\/2\/2022<\/td>\r\n The remaining contents of the Carprofen stock vial and all dilutions made from that vial cannot be used beyond 5\/30\/2022<\/td>\r\n<\/tr>\r\n \r\n On 5\/4\/23 Ketamine (Ketamine stock bottle has expiration of 9\/6\/23) is diluted with Xylazine (Xylazine stock bottle has expiration of 10\/6\/23) for use as an anesthetic cocktail during surgery<\/td>\r\n The dilution would expire when the first drug in the mixture expires. In this case, the Ketamine expires first. The mixture could not be used beyond 9\/6\/23.<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area_with_subheading","legacy_heading":"Appendix B: Examples of Appropriate Labeling","legacy_subheading":"Appendix B: Examples of Appropriate Labeling","legacy_section_text":" \r\n\r\n
\r\n \r\n\r\n[caption id=\"\" align=\"aligncenter\" width=\"367\"] ![\"Appendix-B_Examples-of-Appropriate-Labeling_Bottle1-e1738175031120.png](\"https:\/\/az.research.umich.edu\/animalcare\/wp-content\/uploads\/sites\/2\/2025\/01\/Appendix-B_Examples-of-Appropriate-Labeling_Bottle1-e1738175031120.png\")
Example 1:<\/strong> Vial of Carprofen labeled with appropriate expiration date<\/em>[\/caption]<\/td>\r\n\r\n\r\n[caption id=\"\" align=\"aligncenter\" width=\"358\"] ![\"Appendix-B_Examples-of-Appropriate-Labeling_Bottle2-e1738175062156.png](\"https:\/\/az.research.umich.edu\/animalcare\/wp-content\/uploads\/sites\/2\/2025\/01\/Appendix-B_Examples-of-Appropriate-Labeling_Bottle2-e1738175062156.png\")
Example 2:<\/strong> Vial of Ketamine and Xylazine labeled with appropriate expiration date<\/em>[\/caption]<\/td>\r\n<\/tr>\r\n<\/tbody>\r\n<\/table>","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area_with_subheading","legacy_heading":"","legacy_subheading":"Appendix C: Beyond Use Date Labeling Template","legacy_section_text":"","legacy_media_position":false,"legacy_media_file":null,"legacy_media_url":"","legacy_glossary_term":null,"legacy_glossary_nids":"","legacy_resource":null,"legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"link_button","legacy_heading":"","legacy_subheading":"","legacy_section_text":"","legacy_media_position":false,"legacy_media_file":null,"legacy_media_url":"","legacy_glossary_term":null,"legacy_glossary_nids":"","legacy_resource":null,"legacy_resource_nids":"","legacy_buttons":[{"legacy_button":{"title":"Beyond Use Date Labeling Template","url":"https:\/\/az.research.umich.edu\/animalcare\/informational\/beyond-use-date-labeling-template\/","target":""},"legacy_import_link":true}]}],"update_notice_type":[51,52,53],"update_notice_start":"2026-02-09 07:45:00","update_notice_end":"2026-05-04 09:30:00","update_notice_text_blocks":[{"update_notice_text":"Summary of Changes<\/strong><\/span><\/h3>\r\n
- \r\n \t
- Change the term \u201cuse-by-date\u201d to \u201cbeyond use date\u201d<\/li>\r\n<\/ul>"},{"update_notice_text":"
Who is Impacted<\/strong><\/span><\/h3>\r\n
- \r\n \t
- Laboratory Staff<\/li>\r\n \t
- ULAM Staff<\/li>\r\n<\/ul>"},{"update_notice_text":"
Impact<\/strong><\/span><\/h3>\r\nReview of updated information as it is relevant to your duties."}],"global_contact_block":true,"contact_name":"","contact_email":"","contact_additional_info":"
- Change the term \u201cuse-by-date\u201d to \u201cbeyond use date\u201d<\/li>\r\n<\/ul>"},{"update_notice_text":"
- Expired medical materials and supplies can be used for non-recovery surgeries or non-recovery procedures provided that their usage does not adversely affect the animal’s well-being or potentially compromise the validity of the scientific study. These items must be:\r\n\t