{"id":2887,"date":"2017-07-13T10:47:03","date_gmt":"2017-07-13T10:47:03","guid":{"rendered":"https:\/\/az.research.umich.edu\/animalcare\/document\/policy-approval-use-hazardous-materials-animal-activities\/"},"modified":"2025-02-17T15:52:55","modified_gmt":"2025-02-17T15:52:55","slug":"policy-approval-use-hazardous-materials-animal-activities","status":"publish","type":"document","link":"https:\/\/az.research.umich.edu\/animalcare\/policies\/policy-approval-use-hazardous-materials-animal-activities\/","title":{"rendered":"Policy on Approval for the Use of Hazardous Materials in Animal Activities"},"template":"","categories":[5,6,7,8,9,10,11,12,13,14,15,16,17,18,19],"tags":[],"content-type":[32],"topic":[65],"update-type":[],"class_list":["post-2887","document","type-document","status-publish","hentry","category-cats","category-chickens-avian","category-cows","category-dogs","category-ferrets","category-fish-amphibians-and-reptiles","category-guinea-pigs","category-hamsters","category-mice","category-other-rodents","category-primates","category-rabbits","category-rats","category-sheep","category-swine","content-type-policies","topic-health-and-safety"],"acf":{"use_legacy_editor":true,"updated_date":"2023-10-02 00:00:00","update_notice":true,"author":"Institutional Animal Care &amp; Use Committee","summary":"This policy enacts those provisions of the following federal and state requirements pertaining to the use of <a class=\"gtip\" href=\"\/animalcare\/glossary\/hazardous-materials\">hazardous materials<\/a> in research, teaching, and testing activities that involve vertebrate animals.\r\n<ul>\r\n \t<li><a href=\"https:\/\/grants.nih.gov\/grants\/olaw\/references\/phspolicylabanimals.pdf\"><em>Public Health Service Policy on Humane Care and Use of Laboratory Animals<\/em><\/a>, published by the Office of Lab Animal Welfare, National Institutes of Health<\/li>\r\n \t<li><a href=\"https:\/\/www.nap.edu\/read\/4988\/chapter\/1\"><em>Occupational Health and Safety in the Care and Use of Research Animals<\/em><\/a>, published by the National Academy of Sciences, 1997<\/li>\r\n \t<li><a href=\"https:\/\/grants.nih.gov\/grants\/olaw\/Guide-for-the-care-and-use-of-laboratory-animals.pdf\"><em>Guide for the Care and Use of Laboratory Animals<\/em><\/a>, published by National Research Council<\/li>\r\n \t<li><a href=\"https:\/\/www.cdc.gov\/labs\/BMBL.html?CDC_AA_refVal=https%3A%2F%2Fwww.cdc.gov%2Fbiosafety%2Fpublications%2Fbmbl5%2Findex.htm\"><em>Biosafety in Microbiological and Biomedical Laboratories 5<sup>th<\/sup> Edition<\/em><\/a>, published by the Centers for Disease Control and Prevention and the National Institutes of Health<\/li>\r\n \t<li>NIH Guidelines for Research Involving Recombinant or Synthetic Nucleic Acid Molecules (<a href=\"https:\/\/osp.od.nih.gov\/biotechnology\/nih-guidelines\/\"><em>NIH Guidelines<\/em><\/a>)<\/li>\r\n \t<li><a href=\"https:\/\/www.selectagents.gov\/\"><em>Federal Select Agent Regulations<\/em><\/a> (7CFR331, 9CFR121, and 42CRF73)<\/li>\r\n \t<li><a href=\"https:\/\/www.michigan.gov\/leo\/-\/media\/Project\/Websites\/leo\/Documents\/MIOSHA\/Standards\/Combined\/CS_GI_431\/CS_GI_431__12-12-2018.pdf?rev=4aedae899e4f4bcd969ff2e493243b79&amp;hash=975CB73897A3D191B73A87D1AF1F53BE\"><em>Hazardous Work in Laboratories<\/em><\/a> rule R325.70101 to R325.70114 of Act 154 Michigan Occupational Safety and Health Act (MIOSHA)<\/li>\r\n \t<li>Code of Federal Regulations, PART 20\u2014Standards For Protection Against Radiation <a href=\"https:\/\/www.nrc.gov\/reading-rm\/doc-collections\/cfr\/part020\/\"><em>Title 10, Part 20<\/em><\/a><\/li>\r\n<\/ul>","button_links":null,"related_content":[2877,2878,3404,3401,3445,3450,3436],"legacy_path":"policy-approval-use-hazardous-materials-animal-activities","legacy_node_id":32,"legacy_related_nids":"21, 22, 153, 18","legacy_content_section":[{"legacy_section_type":"heading","legacy_heading":"Applicability","legacy_subheading":"","legacy_section_text":"","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area","legacy_heading":"","legacy_subheading":"","legacy_section_text":"This policy is applicable to all vertebrate animal activities conducted under the auspices of the University of Michigan (U-M), and applies to all campus locations under the purview of the U-M <a class=\"gtip\" href=\"https:\/\/az.research.umich.edu\/animalcare\/glossary\/institutional-animal-care-use-committee-iacuc\/\">IACUC<\/a>.","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"heading","legacy_heading":"Glossary Definitions","legacy_subheading":"","legacy_section_text":"","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"glossary_terms","legacy_heading":"","legacy_subheading":"","legacy_section_text":"","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":[2493],"legacy_glossary_nids":"1370, 1162","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"heading","legacy_heading":"Policy","legacy_subheading":"","legacy_section_text":"","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area","legacy_heading":"","legacy_subheading":"","legacy_section_text":"Activities involving <a class=\"gtip\" href=\"\/animalcare\/glossary\/hazardous-materials\">hazardous materials<\/a> used in conjunction with vertebrate animals must be done in accordance with the approval of the relevant University oversight committees, where applicable, and in accordance with Environment, Health &amp; Safety (<a class=\"gtip\" href=\"\/animalcare\/glossary\/environment-health-safety-ehs\">EHS<\/a>)-defined engineering control practices, using the appropriate Personal Protective Equipment (<a class=\"gtip\" href=\"https:\/\/az.research.umich.edu\/animalcare\/glossary\/personal-protective-equipment-ppe\/\">PPE<\/a>), and following all applicable safety SOPs and policies.\r\n<ol style=\"list-style-type: decimal\" start=\"1\">\r\n \t<li><strong>Biohazards:<\/strong> Before the <a class=\"gtip\" href=\"https:\/\/az.research.umich.edu\/animalcare\/glossary\/institutional-animal-care-use-committee-iacuc\/\">IACUC<\/a> approves the use of biohazards in animals, approval by the Institutional Biosafety Committee (IBC) is necessary. Animal users provide the required information needed to conduct the risk assessment (e.g., nature of hazard and route of administration) through a submission to the IBC. The review and approval process of the IBC includes EHS staff who specialize in biosafety and who identify appropriate control measures for the work.<\/li>\r\n \t<li><strong>Radioisotopes:<\/strong> Before the IACUC approves the use of radioisotopes in animals, approval by the Radiation Policy Committee (RPC) is necessary. Animal users provide the required information needed to conduct the risk assessment (e.g., nature of hazard, dose, and route of administration) through a submission to the RPC. The review and approval process of the RPC includes EHS staff who specialize in radiation safety and who identify appropriate control measures for the work.<\/li>\r\n \t<li><strong>Chemical hazards:<\/strong> Before the IACUC approves the use in animals of chemicals designated by the National Institute of Occupational Safety and Health (NIOSH) as hazardous drugs, carcinogens, reproductive hazards, nanoparticles, toxic chemicals, or materials that may have serious impact(s) on the environment during release or disposal, EHS provides a review and identifies appropriate control measures. These hazards and information needed to conduct the risk assessment (e.g., nature of hazard, dose, and route of administration) are provided to the IACUC and EHS directly in the animal care and use protocol.<\/li>\r\n \t<li><strong>X-rays and Lasers:<\/strong> Before the IACUC approves the use of X-rays or class 3B or 4 lasers in animals, EHS approves the individual unit being used by the laboratory. EHS works as the liaison to register all radiation-generating machines with the State of Michigan prior to operating the machines. The EHS Radiation Safety Service (RSS) helps ensure compliance with the State of Michigan ionizing radiation rules. EHS RSS also ensures that the campus use of Class 3B or Class 4 lasers complies with regulations, ANSI Standards, and maintains the Laser Safety Program.<\/li>\r\n<\/ol>","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"heading","legacy_heading":"Compliance","legacy_subheading":"","legacy_section_text":"","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area","legacy_heading":"","legacy_subheading":"","legacy_section_text":"The IACUC has been delegated authority by EHS to enforce the provisions of this policy and, if necessary, suspend research or implement sanctions if policy infractions should occur. The delegation includes but is not limited to:\r\n<ol style=\"list-style-type: decimal\" start=\"1\">\r\n \t<li>Monitoring activities covered by this policy;<\/li>\r\n \t<li>Enforcing the implementation of the defined requirements; and<\/li>\r\n \t<li>Implementing sanctions and\/or suspensions.<\/li>\r\n<\/ol>","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null}],"update_notice_type":[51,55,53,54],"update_notice_start":"2023-10-05 21:00:00","update_notice_end":"2024-01-05 21:00:00","update_notice_text_blocks":[{"update_notice_text":"<h3><span style=\"color:#024794\"><strong>Summary of Changes<\/strong><\/span><\/h3>\r\n\r\n<ul>\r\n\t<li>Changed document title from: \u2018<u>Policy on the Use of Hazardous Materials in Animal Activities<\/u>\u2019 to \u2018<u>Policy on Approval for the Use of Hazardous Materials in Animal Activities<\/u>\u2019<\/li>\r\n\t<li>Under \u2018<strong>Policy<\/strong>\u2019: Clarification on how EHS approves the use of x-ray machines and class 3B and 4 lasers<\/li>\r\n<\/ul>\r\n\r\n<p>&nbsp;<\/p>"},{"update_notice_text":"<h3><span style=\"color:#024794\"><strong>Who is Impacted<\/strong><\/span><\/h3>\r\n\r\n<ul>\r\n\t<li>Research Personnel<\/li>\r\n<\/ul>"},{"update_notice_text":"<h3><span style=\"color:#024794\"><strong>Impact<\/strong><\/span><\/h3>\r\n\r\n<ul>\r\n\t<li>It is strongly recommended that research personnel review the updated information in the document.<\/li>\r\n<\/ul>"}],"global_contact_block":true,"contact_name":"","contact_email":"","contact_additional_info":"<p>For questions, additional detail, or to request changes to this policy, please contact the Office of the Assistant Vice President for Research, Director of the Animal Care and Use Office at <a href=\"mailto:acuoffice@umich.edu?subject=In%20regards%20to%20a%20Policy%20on%20the%20Research%20A%20to%20Z%20website&body=(the%20email%20link%20creating%20this%20message%20was%20on%20the%20page%20titled%3A%20%22Policy%20on%20the%20Use%20of%20Hazardous%20Materials%20in%20Animal%20Activities%22)\">acuoffice@umich.edu<\/a> or (734) 763-8028.<\/p>","global_contact_block_select":[3375]},"_links":{"self":[{"href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/document\/2887","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/document"}],"about":[{"href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/types\/document"}],"version-history":[{"count":0,"href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/document\/2887\/revisions"}],"acf:post":[{"embeddable":true,"href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/contact-block\/3375"},{"embeddable":true,"href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/document\/3436"},{"embeddable":true,"href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/document\/3450"},{"embeddable":true,"href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/document\/3445"},{"embeddable":true,"href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/document\/3401"},{"embeddable":true,"href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/document\/3404"},{"embeddable":true,"href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/document\/2878"},{"embeddable":true,"href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/document\/2877"}],"acf:term":[{"embeddable":true,"taxonomy":"update-type","href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/update-type\/54"},{"embeddable":true,"taxonomy":"update-type","href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/update-type\/53"},{"embeddable":true,"taxonomy":"update-type","href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/update-type\/55"},{"embeddable":true,"taxonomy":"update-type","href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/update-type\/51"}],"wp:attachment":[{"href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/media?parent=2887"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/categories?post=2887"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/tags?post=2887"},{"taxonomy":"content-type","embeddable":true,"href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/content-type?post=2887"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/topic?post=2887"},{"taxonomy":"update-type","embeddable":true,"href":"https:\/\/az.research.umich.edu\/animalcare\/wp-json\/wp\/v2\/update-type?post=2887"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}