This document is designed to provide general guidelines about administration of substances to laboratory animals. All procedures must be approved by the Institutional Animal Care & Use Committee (IACUC). The route of administration, intervals between substance administration, dose range, and volume to be administered should be listed in the approved protocol specific to each study.
Food and water restriction can be an important and commonly used research tool in many experimental studies. This restriction has the potential to adversely affect an animal's well-being. In keeping within federal and university guidelines, and policies to minimize pain, distress and discomfort of animals used in research, the following guidelines have been developed for implementing food or water restriction or manipulation in experimental studies involving animals.
Pre-anesthetic fasting (with access to water) does not fall under these guidelines. See the species-specific anesthesia and anesthesia guidelines for recommendations on this topic.
In a natural environment, it is not uncommon for animals to have restricted access to food and/or water throughout the day. “Working” for a food reward is also not a completely foreign activity, as animals in nature must forage or hunt for their food. As long as the periods of deprivation do not exceed the ability of homeostatic mechanisms to compensate, these animals are able to carry out normal activities. Common purposes for using food or water deprivation or restriction:
Common purposes for using food or water deprivation or restriction:
Studies pertaining to metabolism, energy regulation, fluid balance, etc.
Studies pertaining to mechanisms and motivations of hunger and/or thirst.
Studies using hunger or thirst as a motivating force to perform behavioral tasks.
To promote a healthier body condition in an obese or sedentary animal.
Studies analyzing the effects of restriction or manipulation on aging or cancer.
Prior to surgery, to prevent complications such as vomiting and aspiration.
This policy of the University of Michigan (U-M) describes the information required by the Institutional Animal Care and Use Committee (IACUC) to address the need to account for animals produced through in-house breeding.
Professional and regulatory guidelines require the provision of adequate anesthetic and surgical care of research animals, as well as maintenance of permanent anesthetic and surgical medical records. In order to assure that veterinary care is properly provided, U-M has established that specific requirements must be followed.
The intent of this policy is to identity the requirements regarding conscious, unanesthetized physical restraint of animals used in research, teaching or testing activities at the University of Michigan.