When minors turn age 18, and if they are continuing as research participants, they must provide consent using the adult informed consent document. Federal guidance at 45 CFR 46.116 states that “unless the Institutional Review Board (IRB) determines that the requirements for obtaining informed consent can be waived, the investigators should seek and obtain the legally effective informed consent, as described in 45 CFR 46.116, for the now-adult participants for any ongoing interactions or interventions with the participants.”
This includes ongoing use of data or biospecimens collected for a research repository.
The eResearch Regulatory Management application asks for each study enrolling minors (section 10.2 Informed Assent) a participant’s status as a child may change during the study (e.g. reaching the age of majority), and what the plans are for seeking the individual’s consent.