{"id":770,"date":"2018-05-08T07:27:42","date_gmt":"2018-05-08T07:27:42","guid":{"rendered":"https:\/\/az.research.umich.edu\/medschool\/document\/humanitarian-use-device-requirements-u-m-physicians-investigators\/"},"modified":"2026-03-06T13:43:46","modified_gmt":"2026-03-06T18:43:46","slug":"humanitarian-use-device-requirements-u-m-physicians-investigators","status":"publish","type":"document","link":"https:\/\/az.research.umich.edu\/medschool\/guidance\/humanitarian-use-device-requirements-u-m-physicians-investigators\/","title":{"rendered":"Humanitarian Use Device Requirements for U-M Physicians &amp; Investigators"},"template":"","categories":[24],"tags":[],"content-type":[41],"topic":[76,43,44,66,75],"update-type":[97],"class_list":["post-770","document","type-document","status-publish","hentry","category-institutional-review-boards-irbmed","content-type-guidance","topic-adverse-events-other-reportable-information-and-occurrences","topic-eresearch-regulatory-management-errm","topic-fda-drugs-devices-biologics","topic-investigator-study-team-responsibilities","topic-regulations-policies-federal-state-local","update-type-information-only"],"acf":{"use_legacy_editor":true,"updated_date":"2023-11-17 11:00:00","update_notice":true,"author":"IRBMED","summary":"The <a class=\"gtip\" href=\"\/medschool\/glossary\/food-and-drug-administration-fda\">Food and Drug Administration (FDA)<\/a> defines a <a class=\"gtip\" href=\"\/medschool\/glossary\/humanitarian-use-device\">Humanitarian Use Device (HUD)<\/a> as \u201ca <a class=\"gtip\" href=\"\/medschool\/glossary\/medical-device\">medical device<\/a> intended to benefit patients in the treatment or diagnosis of a disease or condition that affects or is manifested in not more than 8,000 individuals in the United States per year.\u201d Because the research has shown a HUD to have only \u201cprobable benefit,\u201d rather than \u201ca reasonable assurance of effectiveness,\u201d every HUD requires IRB approval and oversight, whether for use in clinical care or in research.\r\n\r\nA <a href=\"https:\/\/www.fda.gov\/medical-devices\/humanitarian-device-exemption\/humanitarian-device-exemption-hde-postmarket-activities\">Humanitarian Device Exemption<\/a> (HDE) is an application that is similar to a premarket approval (PMA) application but is exempt from the effectiveness requirements of the Food, Drug and Cosmetic Act (FD&amp;C Act). FDA approval of an HDE authorizes an applicant to market a HUD subject to certain profit and use restrictions.","button_links":null,"related_content":[733,754],"legacy_path":"humanitarian-use-device-requirements-u-m-physicians-investigators","legacy_node_id":312,"legacy_related_nids":"262, 295","legacy_content_section":[{"legacy_section_type":"heading","legacy_heading":"Basic Instructions","legacy_subheading":"","legacy_section_text":"","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area_with_subheading","legacy_heading":"","legacy_subheading":"1. Before submitting an IRBMED application, determine which of the following applies:","legacy_section_text":"<ul>\r\n \t<li>A <a class=\"gtip\" href=\"\/medschool\/glossary\/humanitarian-use-device-hud\">HUD<\/a> will be used for clinical care (HUD Use);<\/li>\r\n \t<li>Safety and effectiveness data will be collected for the <a class=\"gtip\" href=\"\/medschool\/glossary\/approved-decision\">approved<\/a> use; or<\/li>\r\n \t<li>The HUD will be studied for a new indication.<\/li>\r\n<\/ul>\r\nThe first two uses are covered under an <a class=\"gtip\" href=\"\/medschool\/glossary\/food-and-drug-administration-fda\">FDA<\/a>-issued\u00a0<a class=\"gtip\" href=\"\/medschool\/glossary\/humanitarian-device-exemption-hde\">Humanitarian Device Exemption\u00a0(HDE)<\/a>. In most instances, the device\u2019s manufacturer holds the HDE. Occasionally, the UM or other physician is the HDE holder.\r\n\r\nThe third use requires an <a class=\"gtip\" href=\"\/medschool\/glossary\/investigational-device-exemption-ide\">Investigational Device Exemption (IDE)<\/a>. An IDE may be issued either by the IRBMED or by the FDA,\u00a0depending on the risk level\u00a0associated with the use. The <a class=\"gtip\" href=\"\/medschool\/glossary\/sponsor\">sponsor<\/a> (whether physician\/investigator, manufacturer, or other party) holds an IDE to conduct clinical research designed to determine the appropriateness of the device for a new indication.","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area_with_subheading","legacy_heading":"","legacy_subheading":"2. Obtain the HDE number or, if the FDA has granted an IDE, the IDE number.","legacy_section_text":"","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area_with_subheading","legacy_heading":"","legacy_subheading":"3. Follow the steps corresponding to the type of HUD use that you are planning:","legacy_section_text":"<ul>\r\n \t<li>On-label use\u00a0without\u00a0collection of safety and effectiveness data (HUD Use)<\/li>\r\n \t<li>On-label use\u00a0with\u00a0collection of safety and effectiveness (HUD Clinical Investigation)<\/li>\r\n \t<li>Emergency or <a class=\"gtip\" href=\"\/medschool\/glossary\/label-use\">off-label use<\/a> of a HUD approved for use at UM<\/li>\r\n \t<li><a class=\"gtip\" href=\"\/node\/305\">Emergency use<\/a> of a HUD for which\u00a0no\u00a0UM IRB-approved project exist<\/li>\r\n \t<li>Use of a HUD in a clinical investigation designed to determine a device\u2019s suitability for a new indication<\/li>\r\n<\/ul>\r\nSee <strong>Types of HUD Use<\/strong> section (below) for steps corresponding to each of the above uses.","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area_with_subheading","legacy_heading":"","legacy_subheading":"4. See the Required Reporting in HUD Clinical Care section (below) for instructions on reporting adverse events and ORIOs (HUD under an HDE, not an IDE).","legacy_section_text":"<ul>\r\n \t<li><a class=\"gtip\" href=\"\/medschool\/glossary\/adverse-event-ae\">Adverse events<\/a><\/li>\r\n \t<li><a class=\"gtip\" href=\"\/medschool\/glossary\/other-reportable-information-or-occurrence-orio\">Other reportable information or occurrences (ORIO)<\/a><\/li>\r\n<\/ul>","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"heading","legacy_heading":"Types of HUD Use","legacy_subheading":"","legacy_section_text":"","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area_with_subheading","legacy_heading":"","legacy_subheading":"1. On-label use of a HUD in clinical care,\u00a0without\u00a0collection of safety and effectiveness data","legacy_section_text":"<ul>\r\n \t<li>On the eResearch section\u00a0<a href=\"\/medschool\/wp-content\/uploads\/sites\/3\/2024\/12\/01-1-non-exempt.pdf\"><strong>01-1<\/strong><\/a>, select\u00a0<a class=\"gtip\" href=\"\/medschool\/glossary\/humanitarian-use-device-hud\"><strong>Humanitarian Use Device (HUD)<\/strong><\/a> <strong>under an <a class=\"gtip\" href=\"\/medschool\/glossary\/humanitarian-device-exemption-hde\">HDE<\/a>.<\/strong><\/li>\r\n \t<li>eResearch will route you to the required sections, starting with\u00a0<a href=\"https:\/\/az.research.umich.edu\/medschool\/wp-content\/uploads\/sites\/3\/2024\/12\/res_irbmed_eResearch-HUD.pdf\">01-5<\/a>. Include the following in your responses:\r\n<ul>\r\n \t<li>A summary of your proposed use of the device (question 1.8)<\/li>\r\n \t<li>The identity of the HDE holder (If you hold the HDE, state this in box 1.8; otherwise, include it within the documentation uploaded in 1-5.12.)<\/li>\r\n \t<li>Any patient follow-up visits, tests, or other procedures (box 1.8; upload further documentation in 1-5.12.)<\/li>\r\n \t<li>Any screening procedures (questions 1.8, 1-5.3 and 1-5.7)<\/li>\r\n \t<li>A description of the HUD procedure itself (boxes 1.8, 1-5.5, and 1-5.6)<\/li>\r\n \t<li>A copy of the HDE approval order (Upload this in 1-5.12.)<\/li>\r\n \t<li>The product labeling (1-5.3 and 1-5.5, as applicable; if available electronically, explain in text fields and upload documentation in 1-5.12.)<\/li>\r\n \t<li>The patient information packet that may accompany the HUD (Upload this in 1-5.12.)<\/li>\r\n \t<li>The IRBMED-recommended\u00a0<a href=\"\/medschool\/templates\/specialty-informed-consent-templates\/\">HUD informed consent template<\/a> (Upload this in 1-5.13.)<\/li>\r\n<\/ul>\r\n<\/li>\r\n \t<li>Submit the eResearch application and await IRBMED approval.<\/li>\r\n \t<li>After receiving notification of IRBMED approval, you may administer the HUD, according to its <a class=\"gtip\" href=\"\/medschool\/glossary\/approved-decision\">approved<\/a> labeling, without obtaining IRBMED approval for each use. When the device is used off-label or used in an emergency, report the use to the IRB within 5\u00a0calendar days.<\/li>\r\n \t<li>Report to the manufacturer and\/or FDA, as required.<\/li>\r\n \t<li>Submit to the IRBMED all\u00a0required reports (see below).\r\n<ul>\r\n \t<li>Submit to the IRBMED an <a href=\"https:\/\/documentation.its.umich.edu\/node\/1335\">annual renewal application<\/a> prior to project expiration.<\/li>\r\n \t<li>Once you have determined that you will no longer use the HUD at UM, submit an IRBMED <a href=\"https:\/\/documentation.its.umich.edu\/node\/1504\">termination application<\/a>.<\/li>\r\n<\/ul>\r\n<\/li>\r\n<\/ul>","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area_with_subheading","legacy_heading":"","legacy_subheading":"2. On-label use of a HUD in clinical care with collection of safety and effectiveness data","legacy_section_text":"If safety and effectiveness data will support a\u00a0Premarket Approval (PMA)\u00a0application, the <a class=\"gtip\" href=\"\/medschool\/glossary\/food-and-drug-administration-fda\">FDA<\/a> requires you to follow some standard research regulations, with the exception that no <a class=\"gtip\" href=\"\/medschool\/glossary\/investigational-device-exemption-ide\">IDE<\/a> is needed. Complete a <strong>standard eResearch application <\/strong>(application type in <strong><a href=\"\/medschool\/wp-content\/uploads\/sites\/3\/2024\/12\/01-1-non-exempt.pdf\">section 01-1<\/a><\/strong> \"Human Subjects research involving interaction or intervention\"), using the <a href=\"\/medschool\/document\/standard-informed-consent-template\/\">standard informed consent template<\/a> for research studies.\r\n\r\nYou may, however, follow the <strong>\"Required Reporting in HUD Clinical Care\"<\/strong>\u00a0guidance below, rather than <a href=\"\/medschool\/document\/standard-informed-consent-template\/\">standard reporting requirements<\/a>. If so, make note of the study-specific reporting plan\u00a0in eResearch section <a href=\"\/medschool\/wp-content\/uploads\/sites\/3\/2024\/12\/32-1.pdf\">32-1<\/a>.","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area_with_subheading","legacy_heading":"","legacy_subheading":"3. Emergency or off-label use of a HUD approved for use at UM","legacy_section_text":"<ul>\r\n \t<li>Apply consent and patient-protection measures, as required by the FDA.<\/li>\r\n \t<li>IRBMED does not require the investigator to obtain IRB permission ahead of time to use a HUD off-label. However, FDA recommends that the user submit to the HDE holder follow-up information on the patient\u2019s condition following the use. IRBMED requires that this report also be submitted to IRBMED as an <a class=\"gtip\" href=\"\/medschool\/glossary\/other-reportable-information-or-occurrence-orio\">ORIO<\/a> at the same time it is sent to the HDE holder. Also, the investigator is required to submit any adverse events reports to IRBMED as required by the FDA.<\/li>\r\n \t<li>Submit to the HDE holder follow-up reports, as required by the HDE holder and recommended by the FDA.<\/li>\r\n<\/ul>","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area_with_subheading","legacy_heading":"","legacy_subheading":"4. Emergency use of a HUD for which no UM, IRB-approved project exists","legacy_section_text":"If IRBMED has not yet approved a HUD\u2019s use at UM, follow FDA regulations for <a class=\"gtip\" href=\"\/node\/305\">emergency use<\/a> of an unapproved device. You must also follow any <a class=\"gtip\" href=\"\/medschool\/glossary\/umhs\">UMHS<\/a> requirements for devices used on patients.\r\n\r\n<strong>Within 5 calendar days<\/strong>\u00a0of use of the device, submit to the IRBMED a new\u00a0eResearch\u00a0application for <a href=\"\/medschool\/guidance\/emergency-use-test-article-life-threatening-circumstances\/\">Emergency Use Report<\/a>.\r\n<ul>\r\n \t<li>In eResearch application section <a href=\"https:\/\/az.research.umich.edu\/medschool\/wp-content\/uploads\/sites\/3\/2024\/12\/01-1-non-exempt.pdf\">01-1<\/a>, select\u00a0<strong>Single-patient Expanded Access Device.<\/strong><\/li>\r\n \t<li>eResearch will route you to the required sections, starting with <a href=\"\/medschool\/wp-content\/uploads\/sites\/3\/2024\/12\/res_irbmed_eResearch.Application.Section04-1.2020.08.24.pdf\">01-4<\/a>.\r\n<ul>\r\n \t<li>Use the Expanded Access\u00a0<a class=\"gtip\" href=\"\/medschool\/templates\/specialty-informed-consent-templates\/\">specialty informed consent template<\/a>.<\/li>\r\n \t<li>If the UM physician holds the HDE, indicate this in the application.<\/li>\r\n<\/ul>\r\n<\/li>\r\n \t<li>Report to the manufacturer and\/or FDA, as required.<\/li>\r\n \t<li>Submit all other reports to the IRBMED,\u00a0as required (see below).<\/li>\r\n<\/ul>","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area_with_subheading","legacy_heading":"","legacy_subheading":"5. Use of a HUD in a clinical investigation testing a prospective new indication","legacy_section_text":"Complete a <strong>standard eResearch application<\/strong> (application type in <a href=\"\/medschool\/wp-content\/uploads\/sites\/3\/2024\/12\/01-1-non-exempt.pdf\">section <strong>01-1<\/strong><\/a> \"Human Subjects research involving interaction or intervention\"),\u00a0observing all applicable UM research policies. This type of study falls under the <a class=\"gtip\" href=\"\/medschool\/glossary\/investigational-device-exemption-ide\">Investigational Device Exemption (IDE)<\/a> requirement.\u00a0If the sponsor identifies the proposed use of the device to be <a class=\"gtip\" href=\"\/medschool\/glossary\/non-significant-risk-device-nsr\">non-significant risk<\/a>, the IRBMED can grant an IDE. If the proposed use of the device is deemed to be <a class=\"gtip\" href=\"\/medschool\/glossary\/significant-risk-sr-device\">significant risk<\/a> (see definition in\u00a0<a href=\"https:\/\/www.accessdata.fda.gov\/scripts\/cdrh\/cfdocs\/cfcfr\/CFRSearch.cfm?fr=812.3\">21 CFR 812.3[m]<\/a>), an IDE from the FDA is required. Generally, all off-label uses of a HUD have been designated as significant risk.","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"heading","legacy_heading":"Required Reporting in HUD Clinical Care","legacy_subheading":"","legacy_section_text":"","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area","legacy_heading":"","legacy_subheading":"","legacy_section_text":"<strong><em>(<a class=\"gtip\" href=\"\/medschool\/glossary\/humanitarian-use-device-hud\">HUD<\/a> under an <a class=\"gtip\" href=\"\/medschool\/glossary\/humanitarian-device-exemption-hde\">HDE<\/a>, not an <a class=\"gtip\" href=\"\/medschool\/glossary\/investigational-device-exemption-ide\">IDE<\/a>)<\/em><\/strong>\r\n\r\nSee also FDA guidance on the <a href=\"https:\/\/www.fda.gov\/regulatory-information\/search-fda-guidance-documents\/humanitarian-device-exemption-hde-program\">HDE program<\/a>.","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area_with_subheading","legacy_heading":"","legacy_subheading":"1. Adverse Events","legacy_section_text":"<strong>Within <a class=\"gtip\" href=\"\/medschool\/glossary\/14-calendar-days\">14 calendar days<\/a><\/strong>, UM and\/or the HDE holder must submit to both the <a class=\"gtip\" href=\"\/medschool\/glossary\/food-and-drug-administration-fda\">FDA<\/a> and the <a class=\"gtip\" href=\"\/medschool\/glossary\/institutional-review-board-medical-school-irbmed\">IRBMED<\/a> a Medical Device Report (MDR), informing them of one or both of the following events:\r\n<ul>\r\n \t<li>The HUD appears to have caused or contributed to death or serious injury.<\/li>\r\n \t<li>The HUD appears to have malfunctioned and is likely to cause or contribute to death or serious injury should the malfunction recur.<\/li>\r\n<\/ul>\r\nFDA defines a\u00a0serious<em> injury<\/em>\u00a0as one that:\r\n<ul>\r\n \t<li>is life-threatening;<\/li>\r\n \t<li>results in permanent impairment of a body function;<\/li>\r\n \t<li>results in permanent damage to a body structure;<\/li>\r\n \t<li>necessitates medical or surgical <a class=\"gtip\" href=\"\/medschool\/glossary\/intervention\">intervention<\/a> to preclude permanent impairment of a body function; or<\/li>\r\n \t<li>necessitates medical or surgical intervention to preclude permanent damage to a body structure.<\/li>\r\n<\/ul>\r\nWhen reporting the event, use the eResearch\u00a0<strong>UM Serious Adverse Event<\/strong>\u00a0form.\u00a0\u200bAs Section 32 of the eResearch application is not triggered for the HUD applications, the above outlined AE reporting plan should be followed.","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area_with_subheading","legacy_heading":"","legacy_subheading":"2. Other Reportable Information or Occurrences (ORIO)","legacy_section_text":"\u200b\u200b\u200bFollow the IRBMED <a href=\"\/medschool\/document\/other-reportable-information-or-occurrence-orio\/\">ORIO reporting guidance<\/a>. \u200b\u200b","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"heading","legacy_heading":"Review Process","legacy_subheading":"","legacy_section_text":"","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null},{"legacy_section_type":"text_area","legacy_heading":"","legacy_subheading":"","legacy_section_text":"\u200bThe initial review and approval of an HUD application will be conducted via the \u200bconvened\u200b board review. Continuing review applications can be reviewed via the <a href=\"https:\/\/az.research.umich.edu\/medschool\/document\/expedited-review\/\">expedited process<\/a> \u200b(expedited category #9).\u200b\u200b Amendments will be reviewed per the \u200b\u200bchanges\u200b\u200b\u200b\u200b proposed in the Amendment submission. \u200b\u200bSee also <a href=\"https:\/\/medresearch.umich.edu\/office-research\/about-office-research\/our-units\/institutional-review-boards-irbmed\/irbmed-frequently-asked-questions-faq\">IRBMED FAQ<\/a>, headings \u200b\"Review and Approval Process\" and \"Ongoing Review.\"","legacy_media_position":"","legacy_media_file":"","legacy_media_url":"","legacy_glossary_term":"","legacy_glossary_nids":"","legacy_resource":"","legacy_resource_nids":"","legacy_buttons":null}],"update_notice_type":[97],"update_notice_start":"2023-11-17 08:00:00","update_notice_end":"2023-11-17 08:00:00","update_notice_text_blocks":null,"global_contact_block":false,"contact_name":"","contact_email":"","contact_additional_info":"Contact us at\u00a0<a href=\"mailto:irbmed@umich.edu\">irbmed@umich.edu<\/a>\u00a0or 734-763-4768 \/ (Fax 734-763-1234)\r\n2800 Plymouth Road, Ann Arbor, MI 48109-2800\r\n\r\nA <a href=\"https:\/\/medresearch.umich.edu\/office-research\/about-office-research\/our-units\/institutional-review-boards-irbmed\/irbmed-contacts-roster#irbmed-staff\">list of IRBMED staff<\/a> is available at our website.\r\n\r\nEdited By: <a href=\"mailto:larkspur@umich.edu\">larkspur@umich.edu<\/a>\r\nLast Updated: March 6, 2026 1:40PM","global_contact_block_select":null},"_links":{"self":[{"href":"https:\/\/az.research.umich.edu\/medschool\/wp-json\/wp\/v2\/document\/770","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/az.research.umich.edu\/medschool\/wp-json\/wp\/v2\/document"}],"about":[{"href":"https:\/\/az.research.umich.edu\/medschool\/wp-json\/wp\/v2\/types\/document"}],"version-history":[{"count":1,"href":"https:\/\/az.research.umich.edu\/medschool\/wp-json\/wp\/v2\/document\/770\/revisions"}],"predecessor-version":[{"id":1909,"href":"https:\/\/az.research.umich.edu\/medschool\/wp-json\/wp\/v2\/document\/770\/revisions\/1909"}],"acf:term":[{"embeddable":true,"taxonomy":"update-type","href":"https:\/\/az.research.umich.edu\/medschool\/wp-json\/wp\/v2\/update-type\/97"}],"acf:post":[{"embeddable":true,"href":"https:\/\/az.research.umich.edu\/medschool\/wp-json\/wp\/v2\/document\/754"},{"embeddable":true,"href":"https:\/\/az.research.umich.edu\/medschool\/wp-json\/wp\/v2\/document\/733"}],"wp:attachment":[{"href":"https:\/\/az.research.umich.edu\/medschool\/wp-json\/wp\/v2\/media?parent=770"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/az.research.umich.edu\/medschool\/wp-json\/wp\/v2\/categories?post=770"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/az.research.umich.edu\/medschool\/wp-json\/wp\/v2\/tags?post=770"},{"taxonomy":"content-type","embeddable":true,"href":"https:\/\/az.research.umich.edu\/medschool\/wp-json\/wp\/v2\/content-type?post=770"},{"taxonomy":"topic","embeddable":true,"href":"https:\/\/az.research.umich.edu\/medschool\/wp-json\/wp\/v2\/topic?post=770"},{"taxonomy":"update-type","embeddable":true,"href":"https:\/\/az.research.umich.edu\/medschool\/wp-json\/wp\/v2\/update-type?post=770"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}