- OLAW notice NOT-OD-14-126: “Guidance on Significant Changes to Animal Activities” defines an administrative process that can be used to make certain significant changes to IACUC approved protocols. The IACUC has approved specific changes that can be incorporated into IACUC approved protocols by ULAM Faculty Veterinarians that are either IACUC voting or alternate members using the VVC process. The following changes can be made to animal activities that have already been IACUC approved provided that the proposed change does not increase pain, distress or degree of invasiveness:
i. Modification or refinement of pain relieving medications provided the changes are consistent with the guidance listed as resources below;
ii. A modification of a surgical procedure that reduces the invasiveness or discomfort of the process;
iii. Modifications to genotyping and identification procedures provided the changes are consistent with the guidance listed as resources below;
iv. Pre or post-operative procedures that are consistent with the IACUC approved Guidelines or Policies referenced below;
v. Method of euthanasia as long as any refinements are consistent with acceptable methods described in the American Veterinary Medical Association (AVMA) panel
publication on acceptable methods for euthanizing vertebrate animals.
vi. Change to a non-pharmaceutical grade compound (from a pharmaceutical grade equivalent) due to unavailability or shortage of the pharmaceutical grade version.