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Immunologic Adjuvant

Agents that non-specifically increase immune responses to specific antigens that are weakly immunogenic.

Import Quarantine (IQ)

Standard ten-week quarantine procedures.

Inactive Case

Those involving animals that are no longer being treated and/or monitored. Cases become inactive when:

  • A clinical condition is resolved by the veterinary staff.
  • The animal is euthanized or un-enrolled from study.
  • The animal is transferred to another laboratory or institution.

Inappetence

Loss or lack of appetite.

Individually Housed

Describes animals housed without tactile contact to another animal. Still has visual and olfactory contact with other animals.

Induration

Localized hardening of the soft tissue of the body.

Infectious / Chemical Substance Form

Form that describes the infectious or chemical hazard for each investigator, located in a binder within the containment housing or procedure room.

Infectious Substance (Biologic Substance)

A live organism (e.g. virus, bacteria, rickettsia, fungi, parasite) capable of causing disease in humans/animals, human/animal tissue (normal or diseased) including all human-derived substances.

Infusion

Administration of a substance over time. Time intervals may be drug- or diluent-specific, or based on veterinary recommendation.

Inquiry

The inquiry is an official period used to collect information associated with a report. The purpose is to gather information pertaining to the report that will be used during the ACC assessment.

Institutional Animal Care & Use Committee (IACUC)

Institutional Animal Care & Use Committee. The IACUC is ultimately responsible for approving, requiring modification of, or prohibiting the use of vertebrate animals in research, teaching, and/or testing activities at the University of Michigan. This includes supervision, coordination, training, guidance, and review of every project proposed to include the use of vertebrate animals to ensure that the project has appropriate scientific merit. 

Institutional Official (IO)

Institutional Official (IO). The IO bears ultimate responsibility for the University of Michigan's Animal Care & Use Program. The IO works closely with the Assistant Vice President for Research – Animal Compliance Oversight and Director of the Animal Care & Use Office; the Assistant Vice President for Research – Animal Resources and U-M Attending Veterinarian; and the Institutional Animal Care & Use Committee Chair to oversee all aspects of animal research at the University of Michigan.

Intracranial

Administration of substances into the brain.

Intradermal (ID)

Administration of substances into the dermis.

Intranasal (IN)

Administration of substances into the nose.

Intrapalpebral

Within the palpebrum.

Intraperitoneal (IP)

Administration of substances into the abdominal cavity.

Intrathecal (IT)

Administration of substances into the subarachnoid space (in the spinal canal but not within the spinal cord).

Intratracheal (IT)

Administration of substances within the trachea.

Introduction

The initial observation and attempt to pair house two non-human primates.

Investigation

Lead by the ACC during a convened meeting of at least a quorum of the IACUC; a formal development of a factual record and the examination of that record leading to a decision to determine, for example, whether noncompliance occurred. During the investigation, the IACUC also quantifies the significance of the incident and identifies the appropriate corrective actions to be taken.

IV

Intravenous.

Juvenile fish

Fish that are 30 to 89 dpf.

Juvenile Hymenochirus spp.

5 weeks to 4 months of age

Juvenile tree shrew stage

P30-P60.

Juvenile Xenopus laevis

Starts once metamorphosis is complete which is typically around 6-8 weeks until the animal reaches adulthood.

Juvenile Xenopus tropicalis

Starts once metamorphosis is complete which is typically around 3-6 weeks until the animal reached adulthood.

Kindle

To give birth.

Kitten Milk Replacer (KMR)

A powered milk formula designed for kittens. Can be used for tree shrew pups.

Lab Will Care Log

This form serves as the log sheet for research personnel to indicate care (feed, water, cage change) provided to the animals. These are typically placed on the inside of the animal room door.

Labsan 230C

A citric acid detergent used to pretreat large animal equipment.

Labsan 256CPQ

A multi-purpose, neutral pH germicidal disinfectant and deodorant which is used to sanitize rooms. Use with light purple foamer tip.

  • Dilution .125 oz Labsan 256CPQ per 32 oz. water when using a 32 oz. spray bottle.

Laminar Flow Hood (LFH)

An enclosed workspace with a HEPA filter at the back or top of the unit that provides a controlled, clean workspace by directing a continuous, unidirectional flow of filtered air over the work surface. This airflow helps to prevent contamination of the animals by removing airborne particles, dust, and microorganisms from the room air as its pulled through the filters.

Large Animal

Mammals ranging in size from cat to calf (including NHPs), typically housed in pens or runs.

Large Animal Veterinary Advisory Team (LAVA)

Body of veterinary faculty overseeing care and use of large animals in research.

Large Breed Pig

Pig breeds developed for agriculture that, when fully grown, may reach sizes of approximately 400 – 800 lbs. Common examples include Yorkshire pigs, Hampshire pigs, Landraces, and Durocs.

Larval/Fry fish

0 to 29-day old fish.

Laying Hen

Hen bred specifically for egg laying.

Liquid Cycle

The autoclave cycle to be used for autoclave loads that contain any amount of liquids. This cycle must be used for all supplies coming out of containment housing rooms.

Lixit

The mouthpiece of a water source leading into the cage made of a stainless steel tube that allows the animal free access to water.

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